OneRepublic "Apologize"

The man responsible for helping produce hits for Justin Timberlake, Ginuwine and Missy Elliott also gets props from OneRepublic. Producer, singer songwriter Timbaland added vocals and percussion to "Apologize" and turned it into a world-wide hit in late-2007. The song spent 25 weeks in the Top 10.

Madonna - "Jump"

Arguably Madonna's best dance song since 1990's "Vogue" was "Jump" from her Confessions on a Dancefloor album in 2006.  The song didn't get played by many CHR/Top-40 radio stations, but did climb to #21 on the Hot Adult Contemporary Chart.  Had Madonna waited a couple years for the Timbaland/David Guetta/Calvin Harris era to begin, the song would have been her defining song of the 2000s.